Table 1

Platelet αIIbβ3 integrin antagonists

AntagonistsOther NamesActive MetaboliteCompanyClassReferences
LamifibanRo 44-9883NoHoffmann-La RocheRGD peptidomimetic Weller et al., 1996
EptifibatideIntegrilinNoCor Therapeutics/Schering-PloughCyclic KGD peptide Phillips and Scarborough, 1997
XemilofibanSC-54684ASC-54701ASearleRGD peptidomimetic Nicholson et al., 1995; Zablocki et al., 1995
SibrafibanRo 48-3567Ro 44-3888Hoffmann-La RocheRGD peptidomimetic Weller et al., 1996
LefradafibanBIBU-104BIBU-52, fradafibanBoehringer IngelheimRGD peptidomimetic Muller et al., 1997
RoxifibanDMP754XV459DuPont MerckRGD peptidomimetic Mousa et al., 1998
SR 121787SR 121566ASanofi RechercheRGD peptidomimetic Badorc et al., 1997; Bernat et al., 1999
L-734,217NoMerckRGD peptidomimetic Cook et al., 1996; Bednar et al., 1998
DMP728NoDupont MerckCyclic RGD peptide Mousa et al., 1993, 1994; Bednar et al., 1998
ReoProAbciximab, c7E3NoCentocor/LillyHumanized antibodyTcheng et al., 1994
XJ7351-150 NoDupont MerckCyclic RGD peptide Srivasta et al., 1997

  • ↵1-150  XJ735 is reported to be an αvβ3inhibitor.