Table 1

Parameter fits for the concentration-dependent activation of rSK2 channel currents by chlorzoxazone, 1-EBIO, and zoxazolamine

DrugImaxEC50n1IC50n21-a
μM μM
Chlorzoxazone1.59602.77302
1-EBIO2.09962.69872
Zoxazolamine0.96961.77942
  • 1-a  n2 was constrained to 2 in order to achieve least-square fit convergence.