Effect of lacidipine on MMP-9 and TIMP-1 secretion by human macrophages
| Additions | Secreted Protein | |
|---|---|---|
| MMP-9 | TIMP-1 | |
| μM | ng/ml medium ± S.D. | |
| No addition | 1620 ± 28.8 | 94.1 ± 1.1 |
| Lacidipine (10) | 1365 ± 12.31-150 | 62.3 ± 2.31-150 |
| Lacidipine (20) | 1140 ± 32.41-150 | 35.5 ± 5.71-150 |
Human macrophages were incubated with DMEM containing the indicated concentrations of lacidipine for 24 h. Then the amount of secreted MMP-9 and TIMP-1 was measured by ELISA. Data are the mean ± S.D. of two experiments performed in triplicate.
↵1-150 P < 0.01 versus control (not treated cells).