Table 1

Effects of angiotensin II and VEGF₁₆₅ on the dry mass weight, dye content, and derived vascularity index in the sponges implanted for 7 days and inhibitory effect of KR31372 (0.1, 0.3, and 1 mg/kg p.o.) on groups treated with angiotensin II

Groups	Dry Mass	Dye Content	V.I.
	mg	μg/sponge	μg dye/mg dry weight
Vehicle	13.4 ± 0.3 (9)	92.8 ± 5.9 (9)	6.9 ± 0.3 (9)
VEGF₁₆₅	19.1 ± 0.7 (6)^***	164.8 ± 10.6 (6)^***	8.7 ± 0.7 (6)^**
Angiotensin II	20.7 ± 0.5 (8)^***	167.8 ± 9.3 (8)^***	8.2 ± 0.5 (8)^1-150
⁺KR31372, 0.1 mg/kg	16.3 ± 2.0 (4)^1-151	73.1 ± 4.0 (4)^1-164 ^1-151	4.7 ± 0.8 (4)^1-164
⁺KR31372, 0.3 mg/kg	18.4 ± 1.1 (4)^1-151	77.9 ± 8.6 (4)^1-164 ^1-151	4.2 ± 0.2 (4)^1-164 ^1-151
⁺KR31372, 1.0 mg/kg	18.9 ± 1.0 (4)^1-151	61.8 ± 4.4 (4)^1-164 ^1-151	3.3 ± 0.2 (4)^1-164 ^1-151

VI, vascularity index.
↵1-150 P < 0.05; ** P < 0.01; *** P < 0.001 vs. vehicle.
↵1-151 P < 0.05;
↵1-164 P < 0.01;
^††† P < 0.001 vs. angiotensin II.