Table 2

Effects of D2-like dopamine receptor stimulation on regional incorporation (k2-150)2-a of [3H]arachidonic acid in rats having a unilateral 6-OHDA lesion of the substantia nigra pars compacta

Brain RegionSideTreatment
Vehiclek2-150QuinpiroleButaclamolQuinpirole + Butaclamolk2-150
Motor cortex
 Layer IIntact6.34  ± 0.472-b 9.37  ± 0.742-152 8.37  ± 0.722-151 9.68  ± 0.602-152
Lesioned6.48  ± 0.5310.47  ± 0.762-160 2-152 8.90  ± 1.002-151 9.77  ± 0.602-152
 Layer II–IIIIntact6.30  ± 0.569.25  ± 0.712-152 8.44  ± 0.902-151 9.65  ± 0.592-152
Lesioned6.47  ± 0.582-150 10.49  ± 0.762-160 2-152 8.88  ± 0.942-160 2-151 9.87  ± 0.542-152
 Layer IVIntact6.56  ± 0.5510.02  ± 0.762-152 9.25  ± 1.112-151 10.30  ± 0.622-152
Lesioned6.81  ± 0.6511.46  ± 0.822-160 2-152 9.71  ± 1.132-160 2-151 10.59  ± 0.552-152
 Layer VIntact6.09  ± 0.528.97  ± 0.652-152 8.22  ± 0.989.06  ± 0.552-152
Lesioned6.23  ± 0.5310.25  ± 0.682-160 2-152 8.55  ± 1.089.50  ± 0.572-160 2-152
 Layer VIIntact5.17  ± 0.377.44  ± 0.552-152 6.58  ± 0.817.30  ± 0.402-152
Lesioned5.08  ± 0.338.42  ± 0.602-160 2-152 6.83  ± 0.947.43  ± 0.462-152
 Average motor cortexIntact5.81  ± 0.589.09  ± 0.892-152 8.24  ± 0.882-151 9.25  ± 0.572-152
Lesioned6.04  ± 0.6510.31  ± 0.852-160 2-152 8.77  ± 1.022-150 2-151 9.52  ± 0.562-152
Somatosensory cortex
 Layer IIntact6.84  ± 0.749.19  ± 0.802-151 9.29  ± 0.812-151 9.99  ± 0.522-152
Lesioned7.08  ± 0.792-150 10.08  ± 0.692-160 2-152 9.12  ± 0.722-151 10.53  ± 0.692-150 2-152
 Layer II–IIIIntact7.06  ± 0.849.62  ± 0.872-151 9.43  ± 0.742-151 10.74  ± 0.632-152
Lesioned7.35  ± 0.9610.40  ± 0.832-160 2-152 9.79  ± 0.832-150 2-151 11.19  ± 0.732-150 2-152
 Layer IVIntact7.59  ± 0.9010.64  ± 0.862-152 10.48  ± 0.992-151 11.86  ± 0.802-152
Lesioned7.99  ± 1.022-150 11.71  ± 0.882-160 2-152 10.66  ± 1.012-151 12.31  ± 0.782-160 2-152
 Layer VIntact6.62  ± 0.709.07  ± 0.682-152 9.00  ± 0.932-151 9.91  ± 0.652-152
Lesioned6.84  ± 0.742-150 10.15  ± 0.672-160 2-152 9.22  ± 0.942-151 10.21  ± 0.672-150 2-152
 Layer VIIntact5.33  ± 0.507.19  ± 0.562-151 7.16  ± 0.797.62  ± 0.512-152
Lesioned5.49  ± 0.498.10  ± 0.472-160 2-152 7.18  ± 0.877.77  ± 0.492-152
 Average somatosensory cortexIntact6.83  ± 0.929.79  ± 0.882-151 9.67  ± 0.902-151 10.25  ± 0.612-152
Lesioned6.96  ± 0.9410.62  ± 0.822-160 2-152 9.67  ± 0.932-151 10.52  ± 0.612-160 2-152
Nucleus accumbensIntact5.54  ± 0.707.47  ± 0.642-151 7.38  ± 0.622-151 8.45  ± 0.562-151
Lesioned5.53  ± 0.697.65  ± 0.652-151 7.26  ± 0.652-151 8.49  ± 0.602-152
Anterior cingulate cortexIntact6.68  ± 0.779.90  ± 0.772-152 8.73  ± 0.842-151 10.07  ± 0.512-152
Lesioned6.65  ± 0.8110.62  ± 0.872-160 2-152 8.93  ± 0.932-151 10.33  ± 0.552-150 2-152
Caudate putamen-dorsalIntact5.13  ± 0.766.43  ± 0.576.45  ± 0.442-151 7.46  ± 0.512-152
Lesioned5.34  ± 0.782-150 7.56  ± 0.662-160 2-151 6.95  ± 0.708.07  ± 0.462-160 2-152
Caudate putamen-ventralIntact5.37  ± 0.726.90  ± 0.632-151 7.47  ± 0.452-152 8.40  ± 0.852-152
Lesioned5.57  ± 0.737.78  ± 0.742-160 2-151 7.86  ± 0.512-150 2-152 8.60  ± 0.902-151
Caudate putamen-lateralIntact5.27  ± 0.766.94  ± 0.592-151 7.07  ± 0.472-152 7.78  ± 0.612-152
Lesioned5.57  ± 0.852-150 8.39  ± 0.732-160 2-152 7.41  ± 0.612-151 8.24  ± 0.582-160 2-152
Caudate putamen-medialIntact5.43  ± 0.856.64  ± 0.626.96  ± 0.422-152 8.02  ± 0.612-152
Lesioned5.61  ± 0.882-150 7.41  ± 0.702-160 2-151 7.08  ± 0.582-151 8.18  ± 0.642-152
Globus pallidusIntact3.73  ± 0.384.37  ± 0.395.20  ± 0.282-152 5.65  ± 0.602-151
Lesioned4.06  ± 0.422-160 4.84  ± 0.412-160 5.53  ± 0.382-152 6.17  ± 0.672-150 2-151
Entopeduncular nucleusIntact3.78  ± 0.483.90  ± 0.434.60  ± 0.494.38  ± 0.26
Lesioned3.98  ± 0.532-150 4.12  ± 0.402-150 4.81  ± 0.482-160 4.61  ± 0.29
Subthalamic nucleusIntact6.54  ± 0.719.41  ± 0.922-151 8.59  ± 0.742-151 9.39  ± 0.702-152
Lesioned6.99  ± 0.869.84  ± 0.912-150 2-151 9.00  ± 0.919.89  ± 0.712-160 2-152
Substantia nigra pars reticulataIntact4.32  ± 0.425.88  ± 0.472-151 5.84  ± 0.532-151 6.36  ± 0.792-151
Lesioned4.83  ± 0.432-160 6.82  ± 0.682-160 2-151 6.37  ± 0.502-160 2-151 7.61  ± 0.922-160 2-151
Parafascicular nucleusIntact5.80  ± 0.958.48  ± 0.912-151 7.72  ± 1.068.35  ± 0.712-152
Lesioned6.45  ± 1.102-150 9.26  ± 0.922-160 2-151 8.24  ± 1.042-160 8.79  ± 0.722-160 2-151
Ventroposterior thalamusIntact6.80  ± 0.838.97  ± 0.852-151 8.63  ± 0.939.12  ± 0.722-151
Lesioned7.05  ± 0.899.49  ± 0.792-150 2-151 8.98  ± 1.002-150 9.20  ± 0.782-151
Ventromedial thalamusIntact5.96  ± 0.737.54  ± 0.622-151 8.58  ± 0.902-151 8.63  ± 0.522-152
Lesioned6.19  ± 0.802-150 7.65  ± 0.669.04  ± 0.992-160 2-151 8.85  ± 0.512-152
Ventrolateral thalamusIntact6.05  ± 0.707.52  ± 0.708.79  ± 0.642-152 8.72  ± 0.452-152
Lesioned6.40  ± 0.772-150 7.65  ± 0.709.11  ± 0.682-152 8.75  ± 0.482-152
Lateral habenular nucleusIntact7.79  ± 1.0210.07  ± 0.952-151 10.78  ± 1.052-151 10.42  ± 0.742-152
Lesioned7.83  ± 1.0310.08  ± 0.9710.77  ± 1.192-151 10.44  ± 0.762-151
Pretectal areaIntact6.14  ± 0.897.84  ± 0.562-151 7.44  ± 0.828.09  ± 0.692-151
Lesioned6.19  ± 0.928.05  ± 0.512-152 7.93  ± 0.722-150 2-151 8.97  ± 0.852-150 2-151
Deep layers of superior colliculusIntact5.09  ± 0.666.79  ± 0.412-152 6.83  ± 0.642-151 7.32  ± 0.752-151
Lesioned5.12  ± 0.626.83  ± 0.492-151 7.05  ± 0.682-151 7.53  ± 0.772-151
Lateral midbrain reticular formationIntact3.81  ± 0.345.24  ± 0.352-152 5.51  ± 0.442-152 5.69  ± 0.762-151
Lesioned3.80  ± 0.355.31  ± 0.282-152 5.73  ± 0.532-152 6.00  ± 0.742-151
Pedunculopontine nucleusIntact3.64  ± 0.334.77  ± 0.182-152 5.20  ± 0.492-151 5.50  ± 0.79
Lesioned3.86  ± 0.362-150 5.11  ± 0.182-160 2-152 5.47  ± 0.532-150 2-151 5.79  ± 0.792-151
  • 2-a  k* = (ml s−1g−1) × 104.

  • 2-b  Values are mean ± S.E.M. ofk*; each region of interest was measured in sextuplicate in each of eight rats.

  • 2-150p < 0.05,

  • 2-160p< 0.01 versus intact side by paired t test.

  • 2-151p < 0.05,

  • 2-152p < 0.01 versus vehicle by unpaired t test.