Maximum stimulation and inhibition of spontaneous locomotor activity by pyrazole analogs
| Compound | Compound Alone | Compound with 3 mg/kg Δ9-THC | ||
|---|---|---|---|---|
| Max Stim (Dose) | Max % Inhibit (Dose) | Max Stim (Dose) | Max % Inhibit (Dose) | |
| 3-Substituent | ||||
| O-848 | None (10) | 69% (10) | N.T. | N.T. |
| O-849 | 25% (10) | 48% (30) | N.T. | N.T. |
| O-850 | None (10) | 43% (10) | N.T. | N.T. |
| O-852 | 52% (1) | Stim at 1, 3, and 10 | N.T. | N.T. |
| O-853 | N.T. | N.T. | N.T. | N.T. |
| O-869 | None (30) | 31% (30) | N.T. | N.T. |
| O-870 | None (30) | 46% (30) | N.T. | N.T. |
| O-889 | 31% (1) | 96% (30) | None (3) | 72% (3) |
| O-890 | 4% (30) | Stim at 30 | N.T. | N.T. |
| O-909 | None (30) | 3% (30) | N.T. | N.T. |
| O-910 | 4% (30) | Stim at 30 | N.T. | N.T. |
| O-1043 | 24% (3) | 49% (30) | None (3 and 10) | 88% (3) |
| O-1269 | 7% (1) | 87% (30) | None (1, 3, and 10) | 91% (10) |
| O-1270 | 29% (3) | 80% (30) | None (10) | 87% (10) |
| O-1271 | 54% (3) | 7% (30) | None (3 and 10) | 58% (3) |
| O-1272 | 17% (3) | 54% (30) | N.T. | N.T. |
| O-1398 | None (3, 10, and 30) | 97% (10) | N.T. | N.T. |
| O-1399 | None (3, 10, and 30) | 100% (30) | N.T. | N.T. |
| O-1876 | None (30) | 11% (30) | N.T. | N.T. |
| O-1877 | 5% (30) | Stim at 30 | N.T. | N.T. |
| 1-Substituent | ||||
| O-1253 | 73% (30) | Stim at 1, 3, 10, and 30 | 50% (10) | 89% (0.1) |
| O-1254 | 29% (30) | Stim at 3, 10, and 30 | 13% (30) | Stim at 10 |
| O-1255 | None (3, 10, and 30) | 20% (10) | None (10) | 65% (10) |
| O-1300 | 54% (30) | Stim at 30 | N.T. | N.T. |
| 4- and/or 5-Substituent | ||||
| O-1302 | 2% (10) | 26% (3) | 107% (30) | 74% (0.3) |
| O-1559 | 118% (30) | Stim at 3, 10, and 30 | N.T. | N.T. |
| O-1690 | 18% (30) | 24% (10) | 39% (10) | 88% (0.3) |
| O-1691 | 66% (1) | 15% (3) | 150% (3) | 91% (0.1) |
| O-1704 | 57% (1) | 19% (30) | 49% (10) | 85% (0.3) |
| O-1710 | 4% (1) | 42% (10) | None (0.3, 1, 3, and 10) | 82% (10) |
Maximum (max) % stimulation (stim) and % inhibition (inhibit) produced by pyrazole analogs tested alone (left) and tested in combination with 3 mg/kg Δ9-THC (right). Dose(s) (mg/kg) at which the effect occurred are given in parentheses.
N.T., not tested.