Compound | R | Ki (nM) | SA | TF | RT |
---|---|---|---|---|---|
Δ9-THC1-a | 41 | 0.92 | 2.7 | 2.5 | |
SR141716A | 6.21-b | >301-c | >301-c | >301-c | |
O-848 | 2450 ± 720 | 69% (10)# | N.T. | N.T. | |
O-849 | 108 ± 9 | >30 | >30 | −4 (30)# | |
O-850 | 351 ± 34 | >10 | N.T. | N.T. | |
O-852 | 78 ± 10 | >10 | >10 | >10 | |
O-853 | 388 ± 32 | N.T. | N.T. | N.T. | |
O-869 | 194 ± 11 | >30 | >30 | >30 | |
O-870 | 109 ± 9 | 66% (30)# | >30 | −3 (30)# | |
O-889 | 54 ± 2 | 20 (17–25) | 67% (30)# | 40 (31–52) | |
O-890 | 379 ± 38 | >10 | >10 | >10 | |
O-909 | 216 ± 29 | >30 | >30 | >30 | |
O-910 | 143 ± 15 | >30 | >30 | >30 | |
O-1043 | 53 ± 9 | >30 | >30 | >30 | |
For Tables 1-4: # indicates the maximal effect that was produced by the analog and the dose (mg/kg) at which it occurred in parentheses. “>dose” indicates that 50% activity was not achieved at this dose (mg/kg), which was the highest dose of the compound that was tested. All ED50 values are expressed as μmol/kg (with 95% confidence limits in parentheses).