Effect of various agents on the disposition of plasmid DNA (10 fmol) in the isolated perfused rat liver
| Substrate | E | t̄ | Vd |
|---|---|---|---|
| s | ml/g liver | ||
| None | 0.69 ± 0.04 | 15.1 ± 2.9 | 0.28 |
| Cationic liposomes (50 μg) | 0.36 ± 0.12 | 13.8 ± 1.5 | 0.25 |
| Polylysine (10 μg) | 0.65 ± 0.02 | 12.2 ± 0.2 | 0.23 |
| Polyinosinic acid (10 μg) | 0.06 ± 0.03 | 8.9 ± 0.8 | 0.17 |
Results are mean ± S.E.M. for n = 3.