Hemodynamics
| n | Heart Rate | Mean Blood Pressure | Rate Pressure Product | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 15-min Ischemia | 120-min Reperfusion | Baseline | 15-min Ischemia | 120-min Reperfusion | Baseline | 15-min Ischemia | 120-min Reperfusion | ||
| beats/minute | mm Hg | mm Hg · min−1 · 1000−1 | ||||||||
| Control | 8 | 368 ± 11 | 368 ± 14 | 410 ± 29 | 84 ± 04 | 77 ± 06 | 64 ± 08 | 39 ± 02 | 35 ± 02 | 37 ± 06 |
| IPC | 7 | 337 ± 14 | 314 ± 13 | 324 ± 151-150 | 108 ± 081-150 | 98 ± 12 | 99 ± 071-150 | 45 ± 04 | 36 ± 05 | 41 ± 04 |
| TAN-67 | 7 | 343 ± 10 | 324 ± 11 | 380 ± 22 | 76 ± 05 | 68 ± 05 | 55 ± 05 | 35 ± 03 | 28 ± 03 | 28 ± 02 |
| PD 098059 | 5 | 400 ± 06 | 400 ± 17 | 428 ± 30 | 96 ± 12 | 76 ± 09 | 51 ± 05 | 48 ± 06 | 38 ± 05 | 32 ± 03 |
| PD 098059 +IPC | 7 | 374 ± 20 | 349 ± 19 | 330 ± 161-150 | 115 ± 051-150 | 68 ± 06 | 58 ± 04 | 52 ± 03 | 30 ± 03 | 27 ± 01 |
| PD 098059 +TAN-67 | 6 | 335 ± 15 | 295 ± 181-150 | 362 ± 09 | 77 ± 06 | 56 ± 07 | 46 ± 05 | 35 ± 04 | 23 ± 04 | 24 ± 02 |
Values given as mean ± S.E.M.
IPC, preconditioning induced by one cycle of 5 min of ischemia followed by 5 min of reperfusion; TAN-67, δ1-opioid agonist infused for 15 min prior to ischemia and reperfusion; PD 098059, inhibitor of MEK-1, administered in the absence or presence of IPC or TAN-67.
↵1-150 p < 0.05 vs. control.