Pharmacokinetic parameters of dihydroetorphine after intravenous injection (2 μg/kg)
| Parameters | Calculated Value |
|---|---|
| A(ng/ml) | 4.51 ± 1.24 |
| α (min−1) | 0.184 ± 0.011 |
| B(ng/ml) | 0.778 ± 0.063 |
| β (min−1) | 0.0186 ± 0.0031 |
| k DG · V 1/V DG(min−1) | 0.0682 ± 0.0200 |
| k DGel(min−1) | 0.0326 ± 0.0122 |
| Q/V brain(ml/min/g) | 0.832 ± 0.161 |
| Kpbrain | 5.17 ± 1.46 |
| Q/V cerebellum(ml/min/g) | 0.608 ± 0.259 |
| Kpcerebellum | 1.77 ± 1.80 |
| t 1/2α(min)1-a | 3.77 |
| t 1/2β(min)1-a | 37.2 |
| AUC (ng · min/ml)1-a | 66.3 |
| MRT (min)1-a | 35.8 |
| Cltot(ml/min/kg)1-a | 30.2 |
| Vdss(ml/kg)1-a | 1081 |
| AUCDG(ng · min/ml)1-a 1-b | 117 |
| AUCDG/AUC1-a | 1.76 |
| AUCbrain(ng · min/ml)1-a 1-b | 322 |
| AUCbrain/AUC1-a | 4.86 |
| AUCcerebellum(ng · min/ml)1-a 1-b | 106 |
| AUCcerebellum/AUC1-a | 1.60 |