Table 1

Metabolism of various polyaromatic hydrocarbons by recombinant CYP2F2

SubstratekcatKmSpecificity Constant
min−1 μM M−1s−1
Naphthalene1-a 10435.8  × 105
2-Methylnaphthalene67.63.73.05  × 105
1-Nitronaphthalene17.121.51.33  × 104
Anthracene1-b 0.14 ± 0.04
Benzo[a]pyrene1-b 0.04 ± 0.00
  • 1-a  Activity for recombinant mouse CYP2F2 (Shultz et al., 1999).

  • 1-b  Activity is based on total metabolites formed and is expressed as the mean ± S.D. of three incubations performed using 100 μM substrate.