[3H]DA uptake in human and rat striatal preparations
| Preparation | KmValue | Vmax Value |
|---|---|---|
| nM | pmol/mg protein · 5 min | |
| Cryopreserved human caudate synaptosomes | 42.7 ± 2.3 | 1.55 ± 0.17 |
| Cryopreserved rat striatal synaptosomes | 52.2 ± 5.3 | 20.9 ± 2.6 |
| Fresh rat striatal synaptosomes | 94 ± 13 | 41.7 ± 9.7 |
| Fresh rat striatal postnuclear supernatant | 52.8 ± 5.6 | 181 ± 13 |
K m and V max values were determined by nonlinear regression. The V max values from the three synaptosomal tissue preparations were significantly different (one-way ANOVA, p < 0.01).