Test Compounds | Ki (nM) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Human CB1 | Human CB2 | Selectivity for CB2 | Mouse CB1 | Mouse CB2 | Selectivity for CB2 | Rat CB1 | Rat CB2 | Selectivity for CB2 | |
JTE-907 | 2370 ± 297 | 35.9 ± 7.32 | 66 | 1060 ± 90.0 | 1.55 ± 0.09 | 684 | 1050 ± 35.4 | 0.38 ± 0.1 | 2760 |
SR144528 | 50.3 ± 8.37 | 1.99 ± 0.94 | 25 | 20.1 ± 4.20 | 0.04 ± 0.00 | 503 | 27.6 ± 2.89 | 0.24 ± 0.02 | 115 |
Win55212-2 | 9.87 ± 1.52 | 0.29 ± 0.12 | 34 | 0.41 ± 0.16 | 0.56 ± 0.02 | 0.7 | 0.14 ± 0.07 | 1.30 ± 0.33 | 0.1 |
Δ9-THC | 5.05 ± 0.65 | 3.13 ± 0.34 | 1.6 | 8.33 ± 3.45 | 1.73 ± 0.09 | 4.8 | 13.5 ± 3.81 | 6.80 ± 2.28 | 2 |
Each value represents mean ± S.E.M. of three experiments.