Table 2

Histopathological changes in kidneys in UN control and ARF rats

Histopathological Changes/Grade	Tubular Necrosis		Protein Casts		Medullary Congestion
	−	±	⁺	⁺⁺	⁺⁺⁺	−	±	⁺	⁺⁺	⁺⁺⁺	−	±	⁺	⁺⁺	⁺⁺⁺
	(0	1	2	3	4)	(0	1	2	3	4)	(0	1	2	3	4)
UN control (n = 6)	6	0	0	0	0	6	0	0	0	0	6	0	0	0	0
Vehicle-treated ARF (n = 6)	0	0	0	2	4	0	0	0	1	5	0	0	1	1	4
	(3.67 ± 0.21^2-159)		(3.83 ± 0.17^2-159)		(3.50 ± 0.34^2-159)
ARF ⁺ verapamil 1 mg/kg (n= 6)	0	0	0	3	3	0	0	0	1	5	0	1	2	1	2
	(3.50 ± 0.22)		(3.83 ± 0.17)		(2.67 ± 0.49)
ARF ⁺ KB-R7943 2 mg/kg (n = 6)	0	0	3	1	2	0	0	1	3	2	0	1	3	2	0
	(2.83 ± 0.40)		(3.17 ± 0.31)		(2.17 ± 0.31)
ARF ⁺ KB-R7943 10 mg/kg (n = 6)	0	1	3	2	0	0	1	2	3	0	0	2	4	0	0
	(2.17 ± 0.31^2-150)		(2.33 ± 0.33^2-150)		(1.67 ± 0.21^2-150)

Each value represents the mean ± S.E.M. Drugs were given i.v. immediately after reperfusion. Grades: no changes (− or 0), mild (± or 1), moderate (⁺ or 2), severe (⁺ ⁺ or 3), very severe (⁺ ⁺ ⁺ or 4).

↵2-150 P < 0.01 compared with vehicle-treated ARF rats;
↵2-159 P < 0.01, compared with UN control rats.