Histopathological Changes/Grade | Tubular Necrosis | Protein Casts | Medullary Congestion | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
− | ± | + | ++ | +++ | − | ± | + | ++ | +++ | − | ± | + | ++ | +++ | |
(0 | 1 | 2 | 3 | 4) | (0 | 1 | 2 | 3 | 4) | (0 | 1 | 2 | 3 | 4) | |
UN control (n = 6) | 6 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 |
Vehicle-treated ARF (n = 6) | 0 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 1 | 5 | 0 | 0 | 1 | 1 | 4 |
(3.67 ± 0.212-159) | (3.83 ± 0.172-159) | (3.50 ± 0.342-159) | |||||||||||||
ARF + verapamil 1 mg/kg (n= 6) | 0 | 0 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 5 | 0 | 1 | 2 | 1 | 2 |
(3.50 ± 0.22) | (3.83 ± 0.17) | (2.67 ± 0.49) | |||||||||||||
ARF + KB-R7943 2 mg/kg (n = 6) | 0 | 0 | 3 | 1 | 2 | 0 | 0 | 1 | 3 | 2 | 0 | 1 | 3 | 2 | 0 |
(2.83 ± 0.40) | (3.17 ± 0.31) | (2.17 ± 0.31) | |||||||||||||
ARF + KB-R7943 10 mg/kg (n = 6) | 0 | 1 | 3 | 2 | 0 | 0 | 1 | 2 | 3 | 0 | 0 | 2 | 4 | 0 | 0 |
(2.17 ± 0.312-150) | (2.33 ± 0.332-150) | (1.67 ± 0.212-150) |
Each value represents the mean ± S.E.M. Drugs were given i.v. immediately after reperfusion. Grades: no changes (− or 0), mild (± or 1), moderate (+ or 2), severe (+ + or 3), very severe (+ + + or 4).