Group | Route | BLyS Dose | Dosing Day | Necropsy Day |
---|---|---|---|---|
mg/kg | ||||
1 | s.c. | Vehicle | 1, 2, 3, 4 | 5 |
2 | i.v. | Vehicle | 1, 2, 3, 4 | 5 |
3 | s.c. | 0.3 | 1, 2, 3, 4 | 5 |
4 | i.v. | 0.3 | 1, 2, 3, 4 | 5 |
5 | s.c. | 3.0 | 1, 2, 3, 4 | 5 |
6 | i.v. | 3.0 | 1, 2, 3, 4 | 5 |
7 | s.c. | Vehicle | 1–14 | 15 |
8 | i.v. | Vehicle | 1–14 | 15 |
9 | s.c. | 0.3 | 1–14 | 15 |
10 | i.v. | 0.3 | 1–14 | 15 |
11 | s.c. | 3.0 | 1–14 | 15 |
12 | i.v. | 3.0 | 1–14 | 15 |