BLyS dosing schedule for determining the effects of route on serum and salivary immunoglobulin concentration
| Group | Route | BLyS Dose | Dosing Day | Necropsy Day |
|---|---|---|---|---|
| mg/kg | ||||
| 1 | s.c. | Vehicle | 1, 2, 3, 4 | 5 |
| 2 | i.v. | Vehicle | 1, 2, 3, 4 | 5 |
| 3 | s.c. | 0.3 | 1, 2, 3, 4 | 5 |
| 4 | i.v. | 0.3 | 1, 2, 3, 4 | 5 |
| 5 | s.c. | 3.0 | 1, 2, 3, 4 | 5 |
| 6 | i.v. | 3.0 | 1, 2, 3, 4 | 5 |
| 7 | s.c. | Vehicle | 1–14 | 15 |
| 8 | i.v. | Vehicle | 1–14 | 15 |
| 9 | s.c. | 0.3 | 1–14 | 15 |
| 10 | i.v. | 0.3 | 1–14 | 15 |
| 11 | s.c. | 3.0 | 1–14 | 15 |
| 12 | i.v. | 3.0 | 1–14 | 15 |