Table 3

SB 239063 intravenous infusions, dose regimens, and plasma concentrations^3-a

Solution Concentration	Target Plasma Concentration	Plasma Concentration^3-b	Total Dose
mg/ml	μg/ml	μg/ml	mg/kg
1.0	1.50	1.52 ± 0.015	10.0
0.5	0.75	0.71 ± 0.02	5.0
0.25	0.38	N.D.	2.5

N.D., not determined.
↵3-a Infusions began 15 min poststroke; infusion rates were 4.5 ml/h/kg for 1 h then 1.1 ml/h/kg for 5 h. More complete graphic presentations, including brain levels, are provided in Fig. 2.
↵3-b Measured in separate groups of SHR (n = 6 rats/dose regimen) after 6-h infusion.