Table 3

Statistical results of cytokines production (area under the curve and peak effects from 0 to 6 h, n = 6)

VariableANOVA (df)3-aTukey Multiple Comparison Test
PlaceboMDMAAlcohol
FpValueAlcoholMDMAMDMA-OHAlcoholMDMA-OHMDMA-OH
Cytokine production
 IL-1βAUC14.769<0.001 3-160 N.S. 3-160 3-160 3-160 N.S.
Peak19.226<0.001 3-160 N.S. 3-160 3-160 3-160 N.S.
C3-150T6.147<0.0011, 1.5, 2, 6N.S.1, 1.5, 2, 61, 1.5, 2, 61, 1.5, 2, 6N.S.
 IL-2AUC99.040<0.001 3-160 3-160 3-160 3-160 N.S. 3-160
Peak115.102<0.001 3-160 3-160 3-160 3-160 N.S. 3-160
C3-150T13.658<0.0011, 1.5, 2, 61, 1.5, 2, 6, 241, 1.5, 2, 6, 241, 1.5, 2N.S.1, 1.5, 2, 6, 24
 IL-4AUC67.950<0.001N.S. 3-160 3-160 3-160 N.S. 3-160
Peak56.090<0.001N.S. 3-160 3-160 3-160 N.S. 3-160
C3-150T32.118<0.001N.S.2,6, 242, 6, 242, 6, 24N.S.2, 6, 24
 IL-6AUC64.675<0.001 3-160 3-160 3-160 3-150 3-150 3-160
Peak119.369<0.001 3-160 3-160 3-160 N.S. 3-160 3-160
C3-150T17.388<0.0012, 61, 1.5, 2, 61, 1.5, 2, 61, 1.5, 22, 61, 1.5, 2, 6
 IL-10AUC167.702<0.001 3-160 3-160 3-160 3-160 3-150 3-160
Peak76.985<0.001 3-160 3-160 3-160 3-160 N.S. 3-160
C3-150T28.713<0.0011.5, 21, 1.5, 2, 61, 1.5, 2, 61, 1.5, 2, 6N.S.1, 1.5, 2, 6
 TNFαAUC53.297<0.001 3-160 3-160 3-160 3-160 N.S. 3-160
Peak67.511<0.001 3-160 3-160 3-160 3-160 N.S. 3-160
C3-150T15.290<0.0012, 61.5, 2, 61.5, 2, 61.5, 2, 6N.S.1.5, 2, 6
 IFNγAUC71.976<0.001N.S. 3-160 3-160 3-160 N.S. 3-160
Peak75.818<0.001N.S. 3-160 3-160 3-160 N.S. 3-160
C3-150T19.467<0.001N.S.1, 1.5, 2, 61.5, 2, 61, 1.5, 2, 6N.S.1, 1.5, 2, 6
 TGFβ1 AUC48.923<0.001N.S. 3-160 3-160 3-160 3-150 3-160
Peak38.696<0.001N.S. 3-160 3-160 3-160 N.S. 3-160
C3-150T14.732<0.0012, 61.5, 2, 61.5, 2, 61.5, 2, 661.5, 2, 6

  • MDMA-OH, MDMA and alcohol combination; N.S., not significant; blank, not done (ANOVA not significant).

  • ↵3-150  p < 0.05.

  • ↵3-160  p < 0.01.

  • ↵3-a  df 3,15 for AUC and peak; df 15,75 for C*T.