Table 3

The area under the specific binding curve (AUC0–120) in rat tissues from 0 to 120 min after i.v. injection of [3H]KMD-3213 and [3H]prazosin

TissueAUC0–120 of Specific Binding
[3H]KMD-3213[3H]Prazosin
min · fmol/mg tissue
Prostate34.9  ± 3.23-160 14.7  ± 2.6
Vas deferens43.5  ± 6.558.0  ± 7.6
Aorta12.4  ± 2.33-160 41.5  ± 7.6
Submaxillary gland123  ± 163-160 39.6  ± 7.3
Spleen7.7  ± 2.83-165 101  ± 18
Heart185  ± 18257  ± 47
Lung162  ± 173-160 96.1  ± 7.4
Liver0.5  ± 3.23-160 37.6  ± 11.8
Kidney140  ± 20137  ± 29

The AUC0–120 values were calculated from the mean value of specific binding at each time shown in Figs. 4 and 5. Each value represents the mean ± S.D. of 10 to 12 rats.

  • Asterisks show a significant difference from the values for [3H]prazosin,

  • ↵3-160 P < 0.01,

  • ↵3-165 P < 0.001.