The in vitro inhibition of specific [3H]KMD-3213 binding in rat prostate by KMD-3213, tamsulosin, prazosin, and terazosin
| Drugs | nH | Ki |
|---|---|---|
| pM | ||
| KMD-3213 | 1.14 ± 0.11 | 213 ± 37 |
| Tamsulosin | 1.01 ± 0.11 | 26.3 ± 5.8 |
| Prazosin | 0.92 ± 0.08 | 116 ± 3 |
| Terazosin | 0.87 ± 0.11 | 1620 ± 300 |
The in vitro inhibition by KMD-3213, tamsulosin, prazosin, and terazosin of specific [3H]KMD-3213 (0.15 nM) binding in homogenates of rat prostate was measured and thenH and Ki values were estimated. Each value represents mean ± S.E. of three rats.