EC50 and Emax for inotropic activity of compounds 3 and 1 in spontaneously beating and in electrically driven left atria from reserpine-treated guinea pigs
| Atrium | Compound1 | Compound 3 | ||
|---|---|---|---|---|
| EC50 | Emax | EC50 | Emax | |
| μM | % | μM | % | |
| Spontaneous | 36.0 ± 6.6 | 46.6 ± 0.9 | 42.2 ± 9.9 | 91.5 ± 1.1 |
| Driven | 22.5 ± 6.9 | 51.7 ± 1.581-a | 53.3 ± 8.81-b | 137.6 ± 1.01-c |
All data are means ± S.E.M. of values from results of six experiments. Statistical significance was calculated by Student'st test.
%, percentage of contractile response to 1 μM noradrenaline.
↵1-a Marginally significant difference (P = .05) vs. Emax of the same compound in spontaneously beating atria.
↵1-b Significantly different vs. EC50 of compound 1 in electrically driven atria.
↵1-c Significantly different vs.Emax of the same compound in spontaneously beating atria.