Effect of 2,3-butanedione monoxime, EMD 57033, and CGP 48506 on parameters of force and myosin-ATPase activity in skinned fiber preparations of human failing left ventricular myocardium
| BDM | EMD | CGP | |
|---|---|---|---|
| Force | |||
| Maximum | ↓↓ | ↑ | = |
| Ca2+sensitivity | ↓ | ↑ | ↑ |
| Cooperativity | ↑ | = | ↑ |
| Myosin-ATPase | |||
|---|---|---|---|
| Maximum | ↓↓ | = | ↓ |
| Ca2+sensitivity | ↓ | = | ↑ |
| Cooperativity | ↑ | = | ↑ |
| Tension Cost | |||
|---|---|---|---|
| ↑↑ | ↓↓ | ↓↓ | |