Prepulse inhibition
| Compound | Dose | Startle Amplitude | Prepulse Inhibition | |||||
|---|---|---|---|---|---|---|---|---|
| PA1 | PA2 | PA3 | PPP, 8 db | PPP, 12 db | PPP, 16 db | N | ||
| mg/kg | g | % | ||||||
| MPEP (p.o., 60 min) | 0 | 196 ± 19 | 154 ± 25 | 147 ± 32 | 38 ± 6 | 60 ± 2 | 83 ± 4 | 7 |
| 1 | 180 ± 22 | 172 ± 20 | 141 ± 28 | 47 ± 2 | 61 ± 5 | 90 ± 2 | 8 | |
| 3 | 199 ± 22 | 200 ± 15 | 168 ± 20 | 39 ± 7 | 57 ± 4 | 88 ± 2 | 8 | |
| 10 | 197 ± 23 | 196 ± 26 | 166 ± 12 | 43 ± 4 | 57 ± 6 | 90 ± 3 | 8 | |
| P | >.05 | >.05 | >.05 | >.05 | >.05 | >.05 | ||
| (+)-MK801 (s.c., 30 min) | 0 | 202 ± 28 | 186 ± 26 | 140 ± 35 | 31 ± 5 | 53 ± 4 | 86 ± 3 | 8 |
| 0.1 | 579 ± 29 | 526 ± 20 | 497 ± 22 | 7 ± 5 | 18 ± 5 | 33 ± 5 | 8 | |
| P | <.001 | <.001 | <.001 | <.01 | <.001 | <.001 | ||
Values represent the mean (±S.E.M.) effect of a treatment with MPEP (1, 3, or 10 mg/kg; pretreatment time, 60 min), (+)-MK801 (0.1 mg/kg; pretreatment time, 30 min), or their respective vehicles, i.e. 0.5% methylcellulose or saline, on startle amplitude (g) and prepulse inhibition (%).