LP: Form | EP: Form | AC | TF: Mech | TF: Therm | Hot-Plate | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
ID50 (95% CL) | Ratio p.o.:s.c. | ID50 (95% CL) | Ratio p.o.:s.c. | ID50 (95% CL) | Ratio p.o.:s.c. | AD50 (95% CL) | Ratio p.o.:s.c. | AD50(95% CL) | Ratio p.o.:s.c. | AD50 (95% CL) | Ratio p.o.:s.c. | |
S18616 | 0.0012 | 1.3 | 0.004 | 1.3 | 0.004 | 3.3 | 0.4 | 13.3 | 0.5 | 5.0 | 0.10 | 1.7 |
(0.0006–0.0024) | (0.001–0.015) | (0.002–0.007) | (0.1–0.9) | (0.3–1.1) | (0.04–0.3) | |||||||
Dexmedetomidine | 0.009 | 1.5 | 0.02 | 4.0 | 0.07 | 17.5 | >2.5 | >18 | ∼2.5 | 42 | 0.4 | 20.0 |
(0.002–0.04) | (0.01–0.04) | (0.03–0.17) | NC | (0.2–0.9) | ||||||||
Clonidine | 0.06 | 2.0 | 0.07 | 2.3 | 0.05 | 2.5 | 2.0 | 8.7 | 3.4 | 22.7 | >40.0 | |
(0.02–0.17) | (0.02–0.19) | (0.02–0.14) | (0.7–5.1) | (1.6–7.0) |
Doses are in mg/kg, p.o. See Table 4 for s.c. doses.
NC, not accurately computable. All other abbreviations as in Table 4.