Activity of S18616 compared with dexmedetomidine and clonidine upon s.c. administration in tests of potential antinociceptive activity in mice
| LP: Form, ID50 (95% CL) | EP: Form, ID50 (95% CL) | AC, ID50 (95% CL) | TF: Mech, AD50 (95% CL) | TF: Therm, AD50 (95% CL) | Hot-Plate, AD50 (95% CL) | |
|---|---|---|---|---|---|---|
| S18616 | 0.001 | 0.003 | 0.0012 | 0.03 | 0.09 | 0.06 |
| (0.0003–0.002) | (0.001–0.006) | (0.0007–0.002) | (0.02–0.08) | (0.03–0.31) | (0.03–0.13) | |
| Dexmedetomidine | 0.006 | 0.005 | 0.004 | 0.14 | 0.06 | 0.02 |
| (0.003–0.01) | (0.003–0.009) | (0.002–0.009) | (0.03–0.74) | (0.02–0.24) | (0.01–0.04) | |
| Clonidine | 0.03 | 0.03 | 0.02 | 0.23 | 0.15 | >2.5 |
| (0.02–0.05) | (0.01–0.07) | (0.01–0.04) | (0.12–0.46) | (0.07–0.31) |
Doses are in mg/kg, s.c.
LP/EP Form, late/early phase of formalin test; AC, abdominal constriction; Mech, mechanical; Therm, thermal; ID50, inhibitory dose50; AD50, active dose50; and CL, confidence limits.