The effects of Ro 60-0175 on the latency to earn the first cocaine infusion and the mean interinfusion interval for rats self-administering cocaine on the PR schedule
| Dose | Latency to First Infusion | Mean Interinfusion Interval | |
|---|---|---|---|
| mg/kg | s | ||
| Vehicle | 87.4 ± 24.8 | 350.2 ± 42.5 | |
| Ro 60-0175 | 0.3 | 193.4 ± 94.8 | 329.7 ± 49.4 |
| 1 | 272.7 ± 118.7 | 470.5 ± 119.7 | |
| 3 | N.D. | N.D. | |
The mean interinfusion interval was calculated after excluding the intervals before the first and last infusion. Two rats at 3 mg/kg failed to respond at all during the session; therefore, a group mean for both measures was not calculated.
N.D., not determined.