Table 2

Temporal distribution of cocaine infusions taken during a 60-min test session under an FR5TO1-min schedule of reinforcement

DoseTime
0–20 min20–40 min40–60 minTotal
mg/kg number of infusions
Vehicle5.9  ± 0.45.2  ± 0.84.4  ± 0.315.5  ± 1.0
Ro 60-01750.36.2  ± 0.54.4  ± 0.44.2  ± 0.414.8  ± 1.0
13.5  ± 1.02-150 2.6  ± 0.52-160 3.0  ± 0.62-160 9.1  ± 1.62-150
31.5  ± 0.92-160 0.9  ± 0.52-160 1.6  ± 0.92-160 4.0  ± 1.92-160

The effect of Ro 60-0175 pretreatment on these responses is shown.N = 10 rats. Data taken from experiment 3a.

  • 2-150P < 0.05,

  • 2-160P < 0.01 versus vehicle control at the respective time point.