Lack of species differences in AK inhibition
| IC50 | ||
|---|---|---|
| ABT-702 | 5′d-5IT | |
| nM | ||
| Human (placenta) | 3.0 ± 0.8 | 0.8 ± 0.4 |
| hrAKlong | 1.4 ± 0.2 | 3.0 ± 2.4 |
| hrAKshort | 1.2 ± 0.1 | 1.4 ± 0.3 |
| Monkey | 1.2 ± 0.4 | 1.6 ± 0.2 |
| Dog | 1.3 ± 0.4 | 2.3 ± 1.0 |
| Rat | 1.7 ± 0.7 | 1.4 ± 0.3 |
| Mouse | 0.8 ± 0.1 | 1.7 ± 0.7 |
All values are the mean ± S.E.M. of at least three separate observations.