Table 4

Plasma levels of nicotine and cotinine (ng/ml)

GroupsPretreatment TimenNicotineCotinineRatio (Nicotine/Cotinine)
min
Water group1011117  ± 4.5741.9  ± 3.873.06  ± 1.24
0.25-CAFF group108115  ± 2.7337.8  ± 1.823.09  ± 0.46
1.0-CAFF group108114  ± 8.9644.4  ± 5.572.90  ± 0.50
Water group601072.3  ± 3.3372.4  ± 3.501.02  ± 0.06
0.25-CAFF group601069.2  ± 4.0472.2  ± 2.820.96  ± 0.05
1.0-CAFF group601071.7  ± 4.6279.3  ± 2.280.91  ± 0.05

Shown are the mean ± S.E.M. plasma levels of nicotine and cotinine 10 and 60 min after a single subcutaneous injection of nicotine (0.4 mg/kg) in the three experimental groups (number of rats per group as indicated by the n value). The ratio of plasma levels of nicotine and cotinine was calculated in individual animals and then expressed as a group mean ± S.E.M. value.