Table 2

Nicotine discrimination: ANOVA table for the effects of drugs in generalization tests in water- and caffeine-drinking rats trained to discriminate 0.4 mg/kg nicotine from saline

DrugEffect% GeneralizationRates of Responding
dfF ValuePValuedfF ValueP Value
NicotineMain F 2,96 0.102.903 F 2,105 2.482.108
Interaction F 10,96 0.336.969 F 10,105 0.782.646
AmphetamineMain F 2,84 3.639.044 F 2,105 0.216.808
Interaction F 8,84 0.571.799 F 10,105 0.457.914
CocaineMain F 2,84 3.489.049 F 2,105 2.403.115
Interaction F 8,84 0.827.584 F 10,105 1.342.218

Shown are the F values, degrees of freedom (df), and significance levels of difference (P values) revealed by ANOVA of the dose-response functions (percentage of generalization to the training dose of nicotine and changes in rates of responding) for each drug. Two-way repeated measures ANOVA on one repeated factor was used to depict quantitative (main effect) and qualitative (interaction) differences in the effects of drugs on percentage generalization and rates of responding in water, 0.25-CAFF, and 1.0-CAFF groups. The dose-response functions are plotted in Figs. 5 and 6.