Dose | n | Time after Administration (h) | Incidence E/T | ||||
---|---|---|---|---|---|---|---|
0–0.5 | 1–2 | 2–4 | 4–8 | 8–24 | |||
mg/kg, p.o. | % | ||||||
Vehicle | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
10 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
30 | 6 | 2 | 1 | 0 | 0 | 0 | 33 |
100 | 4 | 2 | 2 | 1 | 0 | 0 | 50 |
YM976 (3 to 100 mg/kg) was administered orally, in a suspension with 0.5% MC, to normal male ferrets at a volume of 3 ml/kg. Ferrets showing emesis were observed for 24 h after the administration. The data express the number of ferrets showing emesis in one period. The E/T expresses the incidence of the number of animals showing emesis to the total number of test animals.