Time course and incidence of emetogenicity of YM976 in ferrets
| Dose | n | Time after Administration (h) | Incidence E/T | ||||
|---|---|---|---|---|---|---|---|
| 0–0.5 | 1–2 | 2–4 | 4–8 | 8–24 | |||
| mg/kg, p.o. | % | ||||||
| Vehicle | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
| 10 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| 30 | 6 | 2 | 1 | 0 | 0 | 0 | 33 |
| 100 | 4 | 2 | 2 | 1 | 0 | 0 | 50 |
YM976 (3 to 100 mg/kg) was administered orally, in a suspension with 0.5% MC, to normal male ferrets at a volume of 3 ml/kg. Ferrets showing emesis were observed for 24 h after the administration. The data express the number of ferrets showing emesis in one period. The E/T expresses the incidence of the number of animals showing emesis to the total number of test animals.