Effective doses of YM976 and prednisolone on antigen-induced eosinophil infiltration into the airway and lung IL-5 production in C57Black/6 mice
| Compound | ED50 (mg/kg, p.o.) | |||
|---|---|---|---|---|
| n | Eosinophil Infiltration | n | IL-5 Production | |
| YM976 | 9–10 | 3.6 (1.6–6.5) | 10 | 5.8 (3.6–9.6) |
| Prednisolone | 10 | 0.70 (0.15–1.5) | 10 | 0.66 (0.30–1.1) |
Values in saline control and OA control were defined as 100 and 0% inhibition, respectively. An ED50 value was calculated from percentage of inhibition with linear regression (maximum-likelihood method) of SAS. Each value in parentheses represents 95% confidence limits.