Pretreatment/Treatment | [3H]DA Uptake ± S.E.M. | Striatal 5HT Content |
---|---|---|
fmol/μg protein | pg/μg protein | |
Saline/saline | 0.97 ± 0.04 | 5.20 ± 0.25 |
pCPA/saline | 0.91 ± 0.06 | 0.98 ± 0.122-150 |
Saline/METH | 0.34 ± 0.042-150 | 1.85 ± 0.192-160 |
pCPA/METH | 0.35 ± 0.062-150 | 1.10 ± 0.072-150 |
Rats received pCPA (300 mg/kg i.p.) or saline (1 ml/kg i.p.) 48 h before the first METH or saline administration. Rats then received METH (4 × 10 mg/kg s.c.; 2-h intervals) or saline (4 × 1 ml/kg s.c.; 2-h intervals). Rats were decapitated 1 h after the last METH or saline administration.