Effect of a single oral dose of OPC-51803 on body weight and water intake in female Brattleboro rats
| Body Weight | Water Intake | ||
|---|---|---|---|
| Predosing | Changes | ||
| g | ml/8 h | ||
| Vehicle | 232.1 ± 9.8 | 1.7 ± 2.2 | 70.8 ± 3.9 |
| OPC-51803 (mg/kg, p.o.) | |||
| 0.003 | 228.2 ± 9.6 | −1.4 ± 1.9 | 56.7 ± 3.1 |
| 0.01 | 229.4 ± 7.1 | 2.3 ± 2.8 | 62.3 ± 6.8 |
| 0.03 | 238.2 ± 8.3 | −2.8 ± 4.1 | 53.2 ± 5.3 |
| 0.1 | 231.6 ± 7.9 | 0.7 ± 1.4 | 57.5 ± 8.0 |
| 0.3 | 242.7 ± 8.4 | 4.9 ± 1.8 | 36.7 ± 4.02-160 |
| DDAVP (ng/kg, s.c.) | |||
| 1.0 | 239.8 ± 10.2 | −1.4 ± 2.2 | 52.8 ± 10.0 |
Values are expressed as mean ± S.E.M. of five separate binding experiments performed in duplicate.
↵2-160 P < .01 vs. vehicle.