Inhibition constant (Ki) of OPC-51803, AVP , and DDAVP for rat V2- and V1a-receptors
| Ki | |||
|---|---|---|---|
| Kidney (V2-Receptors) | Liver (V1a-Receptors) | V2/V1a Ratio | |
| OPC-51803 | 49.8 ± 8.1 | 1061 ± 60 | 21 |
| AVP | 1.73 ± 0.15 | 1.00 ± 0.06 | 0.6 |
| DDAVP | 8.57 ± 1.50 | 1357 ± 90 | 158 |
Values are expressed as mean ± S.E.M. of five separate binding experiments performed in duplicate.