Table 4

The affinity of avermectins for the [3H]strychnine binding site at glycine receptors in rat spinal cord

AnalogIC50
nM
L-676,893516
L-640,471156
L-676,863756
L-669,437983
L-656,748218
L-676,8973,180
L-751,53196.7
L-697,960>10,000

Data shown are mean of two determinations, which differed by less than 25%.