L-Number | Compound | PTZ Mouse ED50 | Rotarod Mouse MED | LD50 Mouse |
---|---|---|---|---|
mg/kg, i.p. | ||||
Diazepam | 0.26 | 3 | ||
L-676,893 | AVM A2a | 0.48 | >2.5 | 13.5 |
L-751,531 | 23-Oxo-AVM A2a | 0.49 | 28 | |
L-642,126 | 23-Oxo-AVM B2a | 1.1 | <32 | |
L-652,264 | 23-Methyl-AVM B2a | 2.6 | >6 | <<100 |
L-676,897 | AVM B2a | 2.7 | >6.0 | 50 |
L-676,891 | AVM A1a | 4.6 | 25 | |
L-669,437 | Nemadectin | 7.2 | >40 | 64 |
L-701,023 | Doramectin | 7.2 | ||
L-708,381 | 23-Gem-difluoro-IVM | 9.1 | >40 | |
L-734,873 | 4a-O-MEM-22,23-dihydro-AVM B1 | 11.9 | >40 | |
L-759,154 | 5-MeO-Nemadectin | 12.7 | ||
L-759,536 | 5-MeO-Doramectin | 13.8 | ||
L-676,863 | Abamectin (AVM B1a) | 20.5 | >75 | 26 |
L-638,725 | 22,23-Dihydro-AVM A1a | 21.2 | >80 | |
L-693,752 | 13-Epi-avermectin B1a | 24.8 | 160 | |
L-640,471 | IVM | 28.2 | >300 | 26 |
L-694,554 | 13-Epi-O-MOM-AVM B1a aglycone | 34.1 | >160 | |
L-656,748 | 4"-Deoxy-4"-epi-methylamino-AVM B1a | 34.6 | 33 | |
L-697,960 | 13-Epi-O-MOM-AVM B2a aglycone | 37.9 | >80 | 310 |
L-653,433 | 13-β-chloro-13-desoxy-ivermectin aglycone | 43.3 | >180 | |
L-676,913 | AVM B1a aglycone | 43.9 | >50 | |
L-697,959 | 13-O-MOM-AVM B2a aglycone | 77.1 | >80 | >320 |
L-676,915 | AVM B2a aglycone | >80 | >80 | |
L-699,618 | 4"-O-glucosyl AVM B1a | 160.0 | 160 | |
L-685,869 | 4"-Deoxy-4"-epi-acetylamino-AVM B1a 5-ketoxime | >160 |
Historical LD50 data are shown for comparison.
AVM, avermectin; IVM, 22,23-dihydro-avermectin; MEM, methoxyethoxymethyl; MOM, methoxymethyl; MeO, methoxy; MED, minimum effective dose.