State 4 | State 3 | RCR | ADP/Oxygen | ΔΨ | |
---|---|---|---|---|---|
mV | |||||
Carvedilol (μM) | |||||
0 | 15.57 ± 2.05 | 65.70 ± 2.87 | 4.34 ± 0.42 | 2.01 ± 0.07 | 210.5 ± 4.1 |
5 | 15.82 ± 1.90 | 65.36 ± 3.53 | 4.30 ± 0.48 | 2.05 ± 0.05 | N.D. |
10 | 16.00 ± 1.73 | 65.62 ± 3.25 | 4.36 ± 0.40 | 1.97 ± 0.06 | 203.7 ± 4.4 |
20 | 16.34 ± 2.06 | 68.71 ± 1.47 | 4.45 ± 0.49 | 2.03 ± 0.08 | 200.8 ± 4.5 |
30 | 16.43 ± 1.63 | 71.72 ± 3.34 | 4.30 ± 0.57 | 1.97 ± 0.04 | 197.0 ± 4.7 |
40 | 18.06 ± 1.29 | 71.90 ± 3.69 | 4.24 ± 0.71 | 1.91 ± 0.15 | 194.4 ± 5.3 |
50 | 23.20 ± 1.65 | 72.31 ± 1.90 | 3.18 ± 0.311-150 | 1.80 ± 0.13 | N.D. |
80 | 28.60 ± 3.201-150 | 71.75 ± 1.60 | 2.63 ± 0.361-160 | 1.46 ± 0.111-160 | N.D. |
100 | 62.53 ± 4.031-165 | 69.94 ± 1.67 | 1.14 ± 0.091-165 | 1.29 ± 0.071-165 | 171.3 ± 8.2 |
BM910228 (μM) | |||||
0 | 13.85 ± 1.94 | 69.92 ± 6.56 | 5.22 ± 0.44 | 1.93 ± 0.03 | 224.4 ± 0.5 |
0.12 | 12.99 ± 2.43 | 69.21 ± 6.25 | 5.45 ± 0.55 | 1.91 ± 0.07 | N.D. |
0.25 | 14.53 ± 2.55 | 72.31 ± 5.27 | 5.42 ± 0.78 | 1.92 ± 0.02 | 225.3 ± 2.4 |
0.5 | 14.36 ± 2.35 | 68.71 ± 4.75 | 5.12 ± 0.43 | 1.89 ± 0.05 | 222.8 ± 0.3 |
0.75 | 15.22 ± 2.96 | 71.45 ± 5.90 | 5.15 ± 0.70 | 1.88 ± 0.08 | 220.3 ± 1.3 |
1 | 13.98 ± 2.06 | 66.09 ± 4.17 | 5.21 ± 0.70 | 1.93 ± 0.06 | 219.6 ± 1.1 |