Table 2

Potency ratios for the 18 groups of rats in the tolerance and cross-tolerance experiments

Test AgonistPotency Ratio(95% CL)Potency Ratio(95% CL)
0.003 Etorphine Alone0.003 Etorphine + 3.0 LY235959
Etorphine1.0(0.8–1.3)0.9(0.5–1.8)
Morphine2.2(1.5–3.1)1.2(0.9–1.6)
Dezocine3.4(1.9–6.2)1.2(0.5–2.9)
10.0 Morphine Alone10.0 Morphine + 3.0 LY235959
Etorphine2.5(1.9–3.4)1.4(1.1–2.0)
Morphine2.9(2.0–4.4)1.2(0.9–1.6)
Dezocine2-a 4.0(1.8–9.5)
3.0 Dezocine Alone3.0 Dezocine + 3.0 LY235959
Etorphine4.12-b (2.8–6.1)2.4(1.4–3.7)
Morphine3.5(2.5–5.0)1.7(1.1–2.6)
Dezocine9.62-b (4.9–18.9)2.8(1.5–5.5)

Labels to the left of the columns represent the test drug for a group (Test Agonist). Labels in the columns represent the chronic treatment condition. Values in parentheses represent the 95% confidence limits (CL) for each potency ratio.

  • 2-a  —, values could not be determined.

  • 2-b  Slopes are significantly different at P < .05.