Effect of a single oral dose of OPC-51803 on plasma hormone levels in male Sprague-Dawley rats
| AVP | Renin Activity | Aldosterone | Norepinephrine | Epinephrine | |
|---|---|---|---|---|---|
| pg/ml | ng/ml/h | pg/ml | ng/ml | ng/ml | |
| Vehicle | 0.9 ± 0.1 | 7.51 ± 0.79 | 217 ± 36 | 6.78 ± 0.42 | 3.00 ± 0.35 |
| OPC-51803 (mg/kg, p.o.) | |||||
| 0.03 | 0.9 ± 0.0 | 9.30 ± 3.72 | 200 ± 42 | 10.02 ± 0.70 | 4.04 ± 0.53 |
| 0.1 | 1.6 ± 0.9 | 8.03 ± 2.67 | 343 ± 86 | 10.59 ± 1.364-150 | 4.18 ± 0.53 |
| 0.3 | 0.8 ± 0.1 | 6.08 ± 1.52 | 132 ± 35 | 9.54 ± 1.06 | 3.77 ± 0.43 |
Values are expressed as mean ± S.E.M. of five separate binding experiments performed in duplicate.
↵4-150 P < .05 vs. vehicle.