Effects of 80 mM ethanol on proximal GABAA IPSCs, input resistance, and holding current in hippocampal CA1 pyramidal neurons in selected lines of rats and mice
| Animal Line | IPSC Amplitude | IPSC Area under the Curve | Input Resistance | Δ Holding Current |
|---|---|---|---|---|
| % control | % control | % control | pA | |
| HAS1 rats | 127 ± 111-150 (18) | 133 ± 121-150 (18) | 99 ± 3.4 (14) | −16 ± 10 (18) |
| HAS2 rats | 164 ± 151-150 (12) | 158 ± 8.81-150 (12) | 103 ± 2.7 (12) | −4.0 ± 4.9 (12) |
| ILS mice | 124 ± 6.61-150 (17) | 121 ± 6.31-150 (17) | 104 ± 6.1 (17) | 2.2 ± 4.3 (17) |
| LAS1 rats | 112 ± 7.1 (16) | 117 ± 11 (16) | 102 ± 5.1 (16) | −18 ± 13 (15) |
| LAS2 rats | 101 ± 5.7 (13) | 105 ± 9.0 (13) | 101 ± 3.3 (13) | 15 ± 7.9 (13) |
| ISS mice | 100 ± 5.5 (17) | 103 ± 5.2 (17) | 104 ± 3.7 (17) | 5.2 ± 3.1 (17) |
All values are mean ± S.E.M., and the number of cells tested is shown in parentheses.
↵1-150 P < .05 versus ethanol baseline (average of pre- and washout responses).