Population parameter estimates for the final semiphysiological model shown in Fig. 4
| Parameter | Estimate | RSE | IIV |
|---|---|---|---|
| % | |||
| Leukocytebaseline(cells · 109 · l−1) | 14.0 | 5.9 | 12 |
| k delay(cells−1 · 10−9 · day−1) | 5.7 · 10−5 | 4.9 | N.E. |
| t 1/2,circ(min) | 16 | 3.6 | N.E. |
| Slope (l · mg−1 · day−1) | 0.99 | 45 | 120 |
IIV, interindividual variability; N.E., not estimated in the final model.