Congener specific IC50 for inhibition of LPS-induced μ expression and protein secretion or EC50 for induction of CYP1A1
| Congener | CYP1A1 EC50 | μ/24 h IC50 | μ/48 h IC50 | IgM Secretion IC50 |
|---|---|---|---|---|
| (n = 4) | (n = 5) | (n = 5) | (n = 4) | |
| TCDD | 0.072 ± 0.0141-a | 0.536 ± 0.1391-b | 0.194 ± 0.082 | 0.065 ± 0.021 |
| (n = 4) | (n = 3) | (n = 6) | (n = 4) | |
| HxCDD | 0.632 ± 0.1801-c | 0.617 ± 0.432 | 0.488 ± 0.067 | 0.343 ± 0.0901-d |
| (n = 3) | (n = 5) | (n = 4) | ||
| TriCDD | 0.983 ± 0.0821-c | N.D. | 3.046 ± 0.7751-e 1-f | 1.263 ± 0.2611-g |
N.D., not detected.
↵1-a EC50 and IC50 values (concentration generating half-maximal response) are represented as nanomolar (nM) (mean ± S.E.) and were generated from extensive concentration-response curves that were fitted by a four-parameter logistic curve. Statistical difference between EC50 and IC50 means was determined by a one-way ANOVA followed by a least-significant difference test. P < .05 was considered statistically significant.
↵1-b Significance compared with all other endpoints for TCDD.
↵1-c Significance compared with the CYP1A1 EC50 for TCDD.
↵1-d Significance compared with IgM IC50 for TCDD.
↵1-e Significance compared with CYP1A1 EC50 for TriCDD.
↵1-f Significance compared with μ/48 h IC50 for TCDD and HxCDD.
↵1-g Significance compared with IgM IC50 for TCDD and HxCDD.