Model | Data | k1 | k2 | t1/2(kout) | kome1 (i.v.) | kome2 (i.d.) |
---|---|---|---|---|---|---|
h−1 | h | l/μmol/h | ||||
Basic | A, dog 1 | 1.0 | 5.4 | |||
(18) | (15) | |||||
Basic | A, dog 2 | 2.2 | 3.0 | |||
(31) | (19) | |||||
Back-flow | A, dog 1 | 3.2 | 16 | 1.4 | 23 | |
(57) | (52) | (27) | (58) | |||
Back-flow | A, dog 2 | 1.8 | 22 | 4.2 | 30 | |
(80) | (24) | (81) | (25) | |||
Basic | B | 51 | 1.8 | 0.3 | ||
(22) | (13) | (41) | ||||
Back-flow | B | 0.4 | 2.0 | 54 | 11 | 3.0 |
(38) | (56) | (20) | (34) | (56) |
A, short-term experiments (i.e., intravenous infusions); B, combination of short-term (experiments 4 and 5 in dog 1) and long-term experiments (i.e., intraduodenal single doses).