Table 1

Omeprazole infusion schedules, doses of the experiments, and estimates of pharmacokinetic parameters (CV%) when data for two dogs were pooled for each of six experiments

Experiment No.	Infusion Order	Infusion Time	Rate of Infusion	Total Dose	V	k
		min	nmol/kg, min	nmol/kg	l	min⁻¹
1	I	22.5	0.5	81	0.27 (29)	0.014 (36)
	II	277.5	0.25
2	I	22.5	2	323	0.25 (8)	0.020 (10)
	II	277.5	1
3	I	22.5	2	45	0.34 (17)	0.012 (11)
	II	277.5	0
4	I	22.5	8	1290	0.24 (11)	0.024 (12)
	II	277.5	4
5	I	22.5	8	180	0.30 (8)	0.017 (4)
	II	277.5	0
6	I	22.5	2	180	0.35 (9)	0.019 (19)
	II	134.5	1
	III	143.0	0