Presynaptic inhibition of electrically evoked twitch contractions of the guinea pig ileum by adenosine and RAMH in the absence and presence of drugs that alter intracellular cAMP levels
| Treatment | Percentage Reduction of Twitch Contraction Magnitude | |
|---|---|---|
| Adenosine (2 μM) | RAMH (30 nM) | |
| % (mean ± S.E.) | ||
| Control | 66 ± 7 (5) | 41 ± 9 (6) |
| MDL-12330A | 92 ± 34-160 (5) | 69 ± 84-150 (6) |
| Control | 34 ± 10 (5) | 31 ± 2 (5) |
| (R p)-cAMPS | 41 ± 13 (5) | 26 ± 3 (5) |
| Control | 57 ± 9 (4) | 54 ± 9 (4) |
| SKF-95654 | 51 ± 13 (4) | 41 ± 7 (4) |
| Control | 52 ± 7 (4) | 46 ± 7 (4) |
| Ro-20-1724 | 47 ± 6 (4) | 41 ± 4 (4) |