Effect of AR-C69931MX on whole blood cell counts3-a
| Parameter | Treatment Regimen | Baseline | Time during Saline/Drug Infusion | ||
|---|---|---|---|---|---|
| 1 h | 6 h | 7 h | |||
| RBC count (× 103/ml) | 0.9% saline | 6.9 ± 0.7 | 7.8 ± 0.7 | 6.3 ± 1.1 | 8 ± 0.5 |
| AR-C69931MX | 7.1 ± 1.0 | 6.4 ± 0.9 | 6.8 ± 0.4 | 7.3 ± 0.8 | |
| WBC count (× 103/ml) | 0.9% saline | 5.6 ± 1.1 | 5.2 ± 0.5 | 5.1 ± 0.6 | 6.6 ± 1.0 |
| AR-C69931MX | 8.2 ± 1.6 | 5.9 ± 0.6 | 7.5 ± 0.7 | 8.7 ± 1.5 | |
| Hematocrit (%) | 0.9% saline | 42.9 ± 4.5 | 49.0 ± 4.5 | 37.9 ± 6.4 | 50.4 ± 3.9 |
| AR-C69931MX | 43.6 ± 5.8 | 44.4 ± 6.4 | 42.9 ± 2.6 | 45.1 ± 6.1 | |
| Platelets (× 103/ml) | 0.9% saline | 493.4 ± 125.8 | 387.3 ± 41.3 | 297.6 ± 60.1 | 363 ± 50.8 |
| AR-C69931MX | 364.6 ± 64.5 | 399.7 ± 98.3 | 346.0 ± 23.1 | 373.0 ± 61.1 | |
↵3-a AR-C69931MX infused for 6 h and 15 min at a rate of 4.0 μg/kg/min i.v. The values recorded at 7 h were obtained 60 min after the drug infusion was terminated.