Effect of AR-C69931MX upon primary arterial thrombosis
| 0.9% Saline (n = 5) | AR-C69931MX (4.0 μg/kg/min) (n = 6) | |
|---|---|---|
| Animal body weight (kg) | 8.8 ± 0.5 | 8.5 ± 0.6 |
| Time to occlusion (min)1-a | 105.6 ± 14.9 | 382.5 ± 37.51-b |
| Incidence of occlusion (%) | 100 (5/5) | 16.7 (1/6)1-b |
| Thrombus weight (mg)1-c | 47.0 ± 4.7 | 8.0 ± 3.41-b |
↵1-a For the purpose of statistical analysis, the time to occlusion in five of the six AR-C69931MX-treated animals was considered as 420 min even though vessel patency was present upon termination of the study protocol. One of the animals developed carotid artery occlusion at 195 min after application of the anodal current to the intimal surface of the vessel.
↵1-b P < .05.
↵1-c Thrombus size, as determined by weight, was determined at the conclusion of the experimental protocol. A significantly larger thrombus was retrieved from the carotid arteries of control animals, which received a continuous infusion of 0.9% saline.