Table 2

Body weight, renal response to the water load, serum sodium, and serum osmolality after completing the 10-day treatment with SR121463 or vehicle in the two groups of control and cirrhotic rats included in the protocol

	SR121463	Vehicle
Control rats (n = 22)
Body wt. (g)	544 ± 11	538 ± 14
Percentage of water load excreted	109 ± 4	95 ± 3
mUOsm (mOsm/kg)	53 ± 3	77 ± 16
Serum sodium (mEq/l)	142 ± 1	145 ± 0.6
Serum osmolality (mOsm/kg)	298 ± 4	298 ± 2
Cirrhotic rats (n = 18)
Body wt. (g)	542 ± 30	538 ± 13
Percentage of water load excreted	77 ± 9^2-a ^2-167	27 ± 6^2-159
mUOsm (mOsm/kg)	95 ± 27^2-c	356 ± 97^2-167
Serum sodium (mEq/l)	143 ± 2^2-b	135 ± 1^2-159
Serum osmolality (mOsm/kg)	299 ± 3^2-b	284 ± 2^2-159

With respect to control rats receiving the same treatment (unpaired Student's t test),
↵2-a P < .001;
↵2-b P < .01, and
↵2-c P < .05 vs. vehicle;
↵2-159 P < .001 and
↵2-167 P < .005.