Compound | Dose Range | Maximum Substitution | No. Substituted/ No. Tested | Maximum Antagonism | No. Antagonized/ No. Tested |
---|---|---|---|---|---|
mg/kg | % | % | |||
8-OH-DPAT | 0.3–3.0 (substituted) | 33.4 at 1.0 | 1 /4 | ||
0.3–1.0 (antagonized) | 1.2 at 1.0 | 0 /4 | |||
WAY-100635 | 1.0–10.0 | 15.6 at 10.0 | 0 /4 | 25.0 at 1.0 | 1 /4 |
DOI | 0.3–1.0 | 40.5 at 1.0 | 1 /4 | ||
mCPP | 0.3–3.0 | 66.3 at 1.0 | 3 /6 | ||
SB-200646 | 10.0–100.0 | 25.4 at 10.0 | 1 /4 | 25.2 at 10.0 | 1 /4 |
Ketanserin | 3.0–17.8 | 1.3 at 10.0 | 0 /4 | 0 | 0 /4 |
Ondansetron | 0.01–56.0 (substituted) | 0.0 | 0 /4 | ||
0.01–30.0 (antagonized) | 2.0 at 30 | 0 /4 | |||
Fenfluramine | 0.3–10.0 | 25.2 at 1.0 | 1 /4 | ||
Fluoxetine | 10.0–56.0 | 0.0 | 0 /5 | ||
Venlafaxine | 3.0–56.0 | 18.7 at 56.0 | 0 /4 |